Lennart Hilbert’s group at Karlsruhe Institute of Technology (KIT) explores three-dimensional (3D) organization as the foundation of effective information processing in dense DNA suspensions. In particular, we study the cell nucleus as a highly evolved, DNA-based information processing system. In our work, we visualize the inner workings of the nucleus with live and super-resolution microscopy. We translate our observations into physical principles and information processing strategies by means of physical models and computer simulations. Ultimately, we hope to contribute to cell-embedded DNA computing, and the predictive design of DNA-based hardware.
Our laboratory is part of the Institute of Toxicology and Genetics (ITG), a multi-disciplinary center of biological and chemical research at KIT. Lennart Hilbert is also Junior Professor of Systems Biology/Bioinformatics at the Zoological Institute at KIT. Explore our homepage to learn more about our research, who we are, and possibilities to join our team.